Witnesses said, it the second attack in just over one week targeting Egypt's vital tourism industry.
No group immediately claimed responsibility for the attack in which four Egyptians were wounded, the health ministry said. Islamist militants have killed hundreds of police and soldiers over the past two years in a campaign to topple the Egyptian government, but there have recently been attacks on softer tourist and economic targets.
Gunmen on a motorcycle shot dead two members of Egypt's tourism and antiquities police force on a road near the Giza pyramids last week.
The Interior Ministry said in a statement it had “foiled a terrorist attack” at Karnak and that two assailants had been killed and a third wounded.
It did not give further details. Security sources said the casualties at Karnak included bazaar shop owners and two policemen. According to government officials, no tourists were wounded.
