And on Tuesday, the 45-year-old actress was spotted with a beaming smile on her face while spending time with husband Chris Ivery and daughter Stella during the 61st Taormina Film Festival in Italy.
Pompeo enjoyed a family meal with her loved ones before appearing on a panel for a Q&A discussion on day four of the festivities.
For the event, Ellen was dressed in paisley patterned black and white separates that cloaked her svelte frame.
The star covered her arms with a long sleeve design and also chose a similar print for her long legs.
She completed her look with brown strappy sandals and pulled back her blonde tresses in a loose updo.
September 6 marks the 10 year anniversary since the Italian network, FoxLife aired the Shonda Rhimes-created show.
The recent 11th season of Grey's shocked fans when Patrick Dempsey's character Derek Shepherd was killed off after a horrific car accident.
The last episode saw Ellen's character Meredith Grey as a widow with three children struggling to get back into performing surgeries again with her medical family at Grey Sloan Memorial Hospital.
After the shocking death scene, Ellen tweeted to her loyal Grey's fans: 'Excited to tell the story of how Meredith goes on in the face of what feels like the impossible.'
Husband Chris looked summertime ready in a white Ralph Lauren collared shirt, navy shorts, cream coloured fedora and brown sunglasses.
Five-year-old daughter Stella looked adorable in a mini black jumpsuit.
After lunch with Chris and Stella, Ellen gave a masterclass for the audience attendees.
The occasion was to celebrate the upcoming historic date for all the Italian fans of Grey's Anatomy.
Daily mail
Daily mail
